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Resistin impairs activation of protein C by suppressing EPCR and increasing SP1 expression

  • 编号:
    02ca135c-7fdd-4456-864c-ebfd000040eb
  • 作者:
  • 地址:

    [1]Liaocheng Peoples Hosp, Dept Endocrinol, Liaocheng 252000, Peoples R China.

    [2]Liaocheng Peoples Hosp, Dept Neurol, 67 Dongchang West Rd, Liaocheng 252000, Peoples R China.

    [3]Liaocheng Peoples Hosp, Dept Androl, Liaocheng 252000, Peoples R China.

  • 语种:
    英文
  • 期刊:
    BIOMEDICINE & PHARMACOTHERAPY ISSN:0753-3322 2019 年 109 卷 (930 - 937) ; JAN
  • 收录:
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  • 摘要:

    Endothelial cells are vital to blood coagulation and maintain whole body hemostasis. Binding of endothelial cells to endothelial protein C receptor (EPCR) and thrombomodulin (TM) is essential to the formation of activated protein C (APC), one of the key factors regulating blood coagulation. In our study, we showed that resistin, an adipocyte hormone, suppresses thrombin-induced protein C activation in endothelial cells. Resistin treatment results in a reduction in EPCR expression, but not TM. Mechanistically, we demonstrate that resistin induces expression of the nuclear transcription factor SP-1, which could lead to downregulation of EPCR. Both inhibition and silencing of SP1 protein abolishes abnormal APC generation induced by resistin. Collectively, our data support a new role of resistin in disturbing APC formation.

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  • 推荐引用方式
    GB/T 7714:
    Zhang Pei,Liu Yu,Su Jiangli, et al. Resistin impairs activation of protein C by suppressing EPCR and increasing SP1 expression [J].BIOMEDICINE & PHARMACOTHERAPY,2019,109:930-937.
  • APA:
    Zhang Pei,Liu Yu,Su Jiangli,Bai Jie,&Zhao Shouguo.(2019).Resistin impairs activation of protein C by suppressing EPCR and increasing SP1 expression .BIOMEDICINE & PHARMACOTHERAPY,109:930-937.
  • MLA:
    Zhang Pei, et al. "Resistin impairs activation of protein C by suppressing EPCR and increasing SP1 expression" .BIOMEDICINE & PHARMACOTHERAPY 109(2019):930-937.
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