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Resistin impairs activation of protein C by suppressing EPCR and increasing SP1 expression 期刊论文

编号：

02ca135c-7fdd-4456-864c-ebfd000040eb
作者：

Zhang, Pei(张培)#^[1]Liu, Yu(刘玉)#^[1]Su, Jiangli(苏江利)*^[2]Bai, Jie(白洁)^[1]Zhao, Shikai(赵士凯)^[3]Zhao, Shouguo(赵守国)^[3]
语种：

英文
期刊：

BIOMEDICINE & PHARMACOTHERAPY ISSN：0753-3322 2019 年 109 卷 (930 - 937) ; JAN
收录：
关键词：

Resistin Activated protein C EPCR SP1 HUVEC
摘要：

Endothelial cells are vital to blood coagulation and maintain whole body hemostasis. Binding of endothelial cells to endothelial protein C receptor (EPCR) and thrombomodulin (TM) is essential to the formation of activated protein C (APC), one of the key factors regulating blood coagulation. In our study, we showed that resistin, an adipocyte hormone, suppresses thrombin-induced protein C activation in endothelial cells. Resistin treatment results in a reduction in EPCR expression, but not TM. Mechanistically, we demonstrate that resistin induces expression of the nuclear transcription factor SP-1, which could lead to downregulation of EPCR. Both inhibition and silencing of SP1 protein abolishes abnormal APC generation induced by resistin. Collectively, our data support a new role of resistin in disturbing APC formation.
推荐引用方式
GB/T 7714：

Zhang Pei,Liu Yu,Su Jiangli, et al. Resistin impairs activation of protein C by suppressing EPCR and increasing SP1 expression [J].BIOMEDICINE & PHARMACOTHERAPY,2019,109:930-937.
APA：

Zhang Pei,Liu Yu,Su Jiangli,Bai Jie,&Zhao Shouguo.(2019).Resistin impairs activation of protein C by suppressing EPCR and increasing SP1 expression .BIOMEDICINE & PHARMACOTHERAPY,109:930-937.
MLA：

Zhang Pei, et al. "Resistin impairs activation of protein C by suppressing EPCR and increasing SP1 expression" .BIOMEDICINE & PHARMACOTHERAPY 109(2019):930-937.
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