首页 / 院系成果 / 成果详情页

Circulating miR-145 is associated with plasma high-sensitivity C-reactive protein in acute ischemic stroke patients

  • 编号:
    8f2cd660-b007-4fbc-80a5-08e3f361cc8a
  • 作者:
  • 地址:

    [1]Taishan Med Univ, Med Sch Liaocheng, Liaocheng Peoples Hosp, Dept Neurol, Liaocheng 252000, Shandong, Peoples R China.

    [2]Taishan Med Univ, Med Sch Liaocheng, Liaocheng Peoples Hosp, Cent Lab, Liaocheng 252000, Shandong, Peoples R China.

  • 语种:
    英文
  • 期刊:
    CELL BIOCHEMISTRY AND FUNCTION ISSN:0263-6484 2015 年 33 卷 5 期 (314 - 319) ; JUL
  • 收录:
  • 关键词:
  • 摘要:

    Stroke is a major cerebrovascular disease threatening human health and life with high morbidity, disability and mortality. We aimed to find effective biomarkers for the early diagnosis on stroke. Nine previously reported stroke-associated miRNAs (miR-21, miR-23a, miR-29b, miR-124, miR-145, miR-210, miR-221, miR-223 and miR-483-5p) were measured by quantitative real time-PCR, and plasma high-sensitivity C-reactive protein (hs-CRP) and serum interleukin 6 (IL-6), the pro-inflammation markers in brain injury, were examined by enzyme-linked immunosorbent assay in 146 acute ischemic stroke patients and 96 healthy blood donors. We found that serum miR-145 was significantly increased within 24 h after stroke onset and serum miR-23a and miR-221 were decreased in patients. Moreover, serum miR-145 was strong positively correlated with plasma hs-CRP and moderate positively correlated with serum IL-6. Meanwhile, serum miR-23a and miR-221 were moderate negatively correlated with plasma hs-CRP but not serum IL-6. Importantly, the combination of hs-CRP and serum miR-145 gained a better sensitivity/spectivity for prediction of acute ischemia stroke (area under receiver operating characteristic curve from 0.794 to 0.896). Conclusively, our preliminary findings indicate that serum miR-145 upregulated in acute ischemic stroke might be a new biomarker for acute ischemia stroke evaluation. Copyright (c) 2015 John Wiley & Sons, Ltd.

    收起
  • 推荐引用方式
    GB/T 7714:
    Jia Lihua,Hao Fang,Wang Weihua, et al. Circulating miR-145 is associated with plasma high-sensitivity C-reactive protein in acute ischemic stroke patients [J].CELL BIOCHEMISTRY AND FUNCTION,2015,33(5):314-319.
  • APA:
    Jia Lihua,Hao Fang,Wang Weihua,Qu Yang.(2015).Circulating miR-145 is associated with plasma high-sensitivity C-reactive protein in acute ischemic stroke patients .CELL BIOCHEMISTRY AND FUNCTION,33(5):314-319.
  • MLA:
    Jia Lihua, et al. "Circulating miR-145 is associated with plasma high-sensitivity C-reactive protein in acute ischemic stroke patients" .CELL BIOCHEMISTRY AND FUNCTION 33,5(2015):314-319.
浏览次数:38 下载次数:0 原文链接
浏览次数:38
下载次数:0
打印次数:0
浏览器支持: Google Chrome   火狐   360浏览器极速模式(8.0+极速模式) 
返回顶部