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Identification of Risk Factors for Renal Insufficiency in Primary Membranous Nephropathy 期刊论文

编号：

25D84F8E2328231750C2963530F3470C
作者：

Qi, Lin#*^[1]Fang, Bolong^[1];Fang, Xiao^[2];Yu, Yamin(于亚民)^[3]Wang, Yunqiang^[4];
语种：

英文
期刊：

SAUDI MEDICAL JOURNAL ISSN：0379-5284 2026 年 47 卷 7 期 (1160 - 1167) ; JUL 1
收录：
关键词：

Primary membranous nephropathy Renal insufficiency Risk factors Retrospective analysis
摘要：

Objectives: To identify possible evidence linking certain characteristics associated with primary membranous nephropathy (PMN) to renal failure progression in patients diagnosed with PMN and to establish probable evidence of an association between PMN and other risk factors leading to end-stage renal failure. Methods: A historical investigation was carried out including 436 subjects with PMN, with or without renal insufficiency, who were treated at the No. 82 Division Defense Medical Center of the People's Liberation Army and Liaocheng People's Medical Center during January 2020 and December 2023. Binary logistic regression study was applied to determine possible hazard elements. Binary logistic regression analysis was employed to identify potential risk factors, while the diagnostic capabilities of statistically significant continuous variables were assessed through detector performance feature receiver operating characteristic (ROC) plots. Results: Dichotomous logit regression study detected age, blood uric acid level, 24-hour urinary protein level, crescent formation, and renal tubular atrophy/interstitial fibrosis as independent risk factors for renal insufficiency, while hemoglobin level was a protective factor. The ROC analysis showed that age, 24-hour urine protein, and uric acid level had areas under the curve of 0.711 (p < 0.05), 0.652 (p < 0.05), and 0.60 (p < 0.05), with optimal threshold values of 52.5 years, 4.815 g/24 hour, and 446.5 & micro;mol/L. Conclusion: Advanced age, hyperuricemia, anemia, high proteinuria, crescent formation, and renal tubular atrophy/interstitial fibrosis are significant risk factors for renal insufficiency in PMN patients. These findings may help to facilitate risk categorization and referral patterns.
推荐引用方式
GB/T 7714：

Qi Lin,Fang Bolong,Fang Xiao, et al. Identification of Risk Factors for Renal Insufficiency in Primary Membranous Nephropathy [J].SAUDI MEDICAL JOURNAL,2026,47(7):1160-1167.
APA：

Qi Lin,Fang Bolong,Fang Xiao,Yu Yamin,&Wang Yunqiang.(2026).Identification of Risk Factors for Renal Insufficiency in Primary Membranous Nephropathy .SAUDI MEDICAL JOURNAL,47(7):1160-1167.
MLA：

Qi Lin, et al. "Identification of Risk Factors for Renal Insufficiency in Primary Membranous Nephropathy" .SAUDI MEDICAL JOURNAL 47,7(2026):1160-1167.
入库时间：

8/5/2026 9:11:32 PM
更新时间：

8/5/2026 9:11:32 PM

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