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Identifying potential molecular markers and therapeutic targets for chronic obstructive pulmonary disease using transcriptome sequencing and gene expression chip technology 期刊论文

编号：

47C68E37485118A42C35E04DA8BED492
作者：

Zhang, Lihai#^[1]Zhang, Zhipeng^[2];Yu, Tong(于彤)^[3]Geng, Zhangyan^[4];Yuan, Lindong(袁林栋)*^[3]
语种：

英文
期刊：

ARCHIVES OF MEDICAL SCIENCE ISSN：1734-1922 2025 年 21 卷 6 期 (2720 - 2732)
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关键词：

chronic obstructive pulmonary disease (COPD) pathogenesis RNA-Seq biomarker
摘要：

Introduction: Chronic obstructive pulmonary disease (COPD) is a progressive lung disorder characterized by persistent respiratory symptoms and progressive airflow obstruction. The global rise in COPD incidence and mortality imposes a significant societal burden. Despite its prevalence, the intricate pathogenesis of COPD remains incompletely understood. This study aimed to identify molecular markers and potential therapeutic targets by integrating known COPD-related genes and analyzing RNA-Seq and expression microarray data. Material and methods: We conducted a comprehensive analysis by combining RNA-Seq and expression microarray data for COPD, focusing on known COPD-associated genes. Differential expression analysis revealed insights into the cellular biological processes and signaling pathways underlying COPD pathogenesis. Functional modules closely linked to COPD were identified through protein interaction network analysis. Results: The analysis of differentially expressed genes (DEGs) highlighted the significance of cellular processes such as chemotaxis, cell migration, cellular stress, and apoptosis in COPD pathogenesis. Key signaling pathways, including NF-kappa B, JAK-STAT, T cell receptor, and NOD-like receptor pathways, were identified as crucial contributors to COPD development. Protein interaction network analysis revealed functional modules associated with COPD. Validation through qRT-PCR and immunoblotting confirmed PTX3 and CYP1B1 as core genes, suggesting their potential as biomarkers and therapeutic targets for COPD. Conclusions: Our findings provide valuable insights into the molecular landscape of COPD, identifying PTX3 and CYP1B1 as promising candidates for further investigation as potential biomarkers and therapeutic targets. This research contributes to a better understanding of COPD pathogenesis, offering avenues for the development of targeted interventions to address this escalating global health concern.
推荐引用方式
GB/T 7714：

Zhang Lihai,Zhang Zhipeng,Yu Tong, et al. Identifying potential molecular markers and therapeutic targets for chronic obstructive pulmonary disease using transcriptome sequencing and gene expression chip technology [J].ARCHIVES OF MEDICAL SCIENCE,2025,21(6):2720-2732.
APA：

Zhang Lihai,Zhang Zhipeng,Yu Tong,Geng Zhangyan,&Yuan Lindong.(2025).Identifying potential molecular markers and therapeutic targets for chronic obstructive pulmonary disease using transcriptome sequencing and gene expression chip technology .ARCHIVES OF MEDICAL SCIENCE,21(6):2720-2732.
MLA：

Zhang Lihai, et al. "Identifying potential molecular markers and therapeutic targets for chronic obstructive pulmonary disease using transcriptome sequencing and gene expression chip technology" .ARCHIVES OF MEDICAL SCIENCE 21,6(2025):2720-2732.
入库时间：

2/6/2026 7:22:34 PM
更新时间：

2/6/2026 7:22:34 PM

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