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Neoplastic CD3+ B cells remodel the DLBCL tumor microenvironment via single-cell and spatial transcriptomics 期刊论文

编号：

9006056E70FDA137FC24B932CB1E1A79
作者：

Lang, Mingxiao#^[1]Feng, Youqin#^[1]Zhou, Li^[2];Li, Bin^[3];Li, Wei^[1];Zhao, Jing^[1];Chen, Kexin(陈柯鑫)^[4]Li, Lanfang^[1];Qiu, Lihua^[1];Qian, Zhengzi^[1];Zhou, Shiyong^[1];Zhang, Huilai*^[1]Chu, Zhaobin*^[5]
语种：

英文
期刊：

CANCER BIOLOGY & THERAPY ISSN：1538-4047 2026 年 27 卷 1 期 ; DEC 31
收录：
关键词：

Diffused large B-cell lymphoma CD3 complex tumor microenvironment RNA sequencing spatial transcriptomics
摘要：

IntroductionThis study constructs a high-resolution multi-omics map of Diffuse Large B-Cell Lymphoma (DLBCL) by integrating single-cell, single-nucleus, and spatial transcriptomics.MethodsWe identified a previously unrecognized, recurrent subset of malignant B cells that unexpectedly express CD3, a protein typically found only on T cells. This unusual CD3(+) B cell population appears to be driven by a specific genetic circuit involving five key regulatory genes: BCLAF1, CHURC1, FLI1, NFATC2, and ELF2.ResultSpatial and functional analyses revealed that these cells are associated with macrophage enrichment and M2 polarization, potentially involving TGF-beta signaling and contributing to an immunosuppressive tumor microenvironment. Clinically, the abundance of CD3(+) B cells was associated with advanced disease stage, poor treatment response, and reduced survival.ConclusionOur findings support the presence of a CD3(+) B cell subset with T cell-like features that is associated with tumor microenvironment remodeling and adverse clinical outcomes, highlighting molecular determinants like FLI1 and the TGF-beta axis as potential therapeutic targets.
推荐引用方式
GB/T 7714：

Lang Mingxiao,Feng Youqin,Zhou Li, et al. Neoplastic CD3+ B cells remodel the DLBCL tumor microenvironment via single-cell and spatial transcriptomics [J].CANCER BIOLOGY & THERAPY,2026,27(1).
APA：

Lang Mingxiao,Feng Youqin,Zhou Li,Li Bin,&Chu Zhaobin.(2026).Neoplastic CD3+ B cells remodel the DLBCL tumor microenvironment via single-cell and spatial transcriptomics .CANCER BIOLOGY & THERAPY,27(1).
MLA：

Lang Mingxiao, et al. "Neoplastic CD3+ B cells remodel the DLBCL tumor microenvironment via single-cell and spatial transcriptomics" .CANCER BIOLOGY & THERAPY 27,1(2026).
入库时间：

6/24/2026 9:12:08 PM
更新时间：

6/24/2026 9:12:08 PM

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