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RET Inhibitor SPP86 Triggers Apoptosis and Activates the DNA Damage Response Through the Suppression of Autophagy and the PI3K/AKT Signaling Pathway in Melanoma Cells 期刊论文

编号：

D776A6DD6C7D6DA1E4E62F9125E9624E
作者：

Zhang, Yuli(张玉丽)#^[1,2]Liu, Haidong(刘海东)^[1]Wang, Kun(王坤)^[3]Zheng, Juan^[4];Luan, Hong(栾红)*^[1]Xin, Ming*^[5]
语种：

英文
期刊：

DRUG DESIGN DEVELOPMENT AND THERAPY ISSN：1177-8881 2025 年 19 卷 (67 - 82)
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关键词：

melanoma SPP86 autophagy DNA damage apoptosis PI3k/AKT
摘要：

Background: Melanoma is a highly lethal form of skin cancer, and effective treatment remains a significant challenge. SPP86 is a novel potential therapeutic drug. Nonetheless, the specific influence of SPP86 on autophagy, particularly its mechanisms in the context of DNA damage and apoptosis in human melanoma cells, remains inadequately understood. Thus, this study aims to explore the effects of SPP86 on autophagy and to elucidate its association with cell proliferation, apoptosis, and DNA damage in melanoma cells. Methods: This study assessed the anti-tumor effects of SPP86 on cell viability, colony formation, apoptosis, and DNA damage in two melanoma cell lines, A375 and A2058. Concurrently, the underlying mechanisms, including the PI3K/AKT signaling pathway and autophagy modulation, were also elucidated. Results: The study demonstrated that SPP86 exerts anti-tumor effects in melanoma cells through multiple mechanisms: it induces apoptosis, causes DNA damage, inhibits cell proliferation, and suppresses the PI3K/AKT signaling pathway. Importantly, the inhibition of autophagy appears to be a critical component of SPP86'' s mode of action, with the modulation of autophagic processes influencing the cytotoxicity against melanoma cells. Conclusion: These promising findings suggest that SPP86 is a potential drug candidate for the treatment of melanoma, warranting further research and development.
推荐引用方式
GB/T 7714：

Zhang Yuli,Liu Haidong,Wang Kun, et al. RET Inhibitor SPP86 Triggers Apoptosis and Activates the DNA Damage Response Through the Suppression of Autophagy and the PI3K/AKT Signaling Pathway in Melanoma Cells [J].DRUG DESIGN DEVELOPMENT AND THERAPY,2025,19:67-82.
APA：

Zhang Yuli,Liu Haidong,Wang Kun,Zheng Juan,&Xin Ming.(2025).RET Inhibitor SPP86 Triggers Apoptosis and Activates the DNA Damage Response Through the Suppression of Autophagy and the PI3K/AKT Signaling Pathway in Melanoma Cells .DRUG DESIGN DEVELOPMENT AND THERAPY,19:67-82.
MLA：

Zhang Yuli, et al. "RET Inhibitor SPP86 Triggers Apoptosis and Activates the DNA Damage Response Through the Suppression of Autophagy and the PI3K/AKT Signaling Pathway in Melanoma Cells" .DRUG DESIGN DEVELOPMENT AND THERAPY 19(2025):67-82.
入库时间：

1/22/2025 9:21:52 PM
更新时间：

1/22/2025 9:21:52 PM
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